NAD+
Essential Cellular Coenzyme | Anti-Aging Therapy
Nicotinamide Adenine Dinucleotide (NAD+) is a vital coenzyme found in every cell that plays a crucial role in energy production, DNA repair, and cellular metabolism. As NAD+ levels naturally decline with age, supplementation can support cellular health, boost energy, enhance cognitive function, and promote longevity.
Daily dose
100-1000mg
Frequency
1-3x weekly
Cycle length
4-12 weeks
Storage
2-8°C
Key benefits
Highest bioavailability (100%), rapid cellular uptake, immediate energy enhancement, bypasses digestive limitations
How it works
Direct delivery to bloodstream ensures maximum cellular availability for energy production, DNA repair, and sirtuin activation
Dosage protocols
Goal
General Wellness & Energy
Dose
100-250mg · 1-2x weekly
Route
IV or IM
Goal
Anti-Aging Protocol
Dose
250-500mg · 2-3x weekly
Route
IV infusion
Goal
Cognitive Enhancement
Dose
500-1000mg · 1-2x weekly
Route
IV infusion
Goal
Athletic Performance
Dose
250-500mg · 2x weekly
Route
IM injection
Goal
Recovery & Repair
Dose
500-1000mg · 3x weekly
Route
IV infusion
Goal
Maintenance Therapy
Dose
100-250mg · 1x weekly
Route
SubQ or IM
Research indications
energy Metabolism
anti Aging
neurological Support
Administration
Interactions
Safety notes
Start with lower doses to assess tolerance
IV administration requires medical supervision
Monitor for injection site reactions
Avoid alcohol consumption during treatment
Maintain consistent dosing schedule for best results
Research studies
Intranasal NAD+ for Traumatic Brain Injury (2012)
Rats | 20 mg/kg intranasal | Post-TBI treatment | Hippocampal neuroprotection
Demonstrated that intranasal NAD+ delivery protected hippocampal neurons (CA1, CA3, dentate gyrus) and reduced microglial activation following traumatic brain injury.
View study →Nicotinamide Riboside Safety & Metabolism Study (2019)
Human | 100-1000mg oral daily | 8 weeks | Well-tolerated, increased NAD+
Randomized, double-blind, placebo-controlled clinical trial demonstrating long-term NR administration is safe and effectively elevates NAD+ metabolites in healthy overweight adults.
View study →Age-Associated NAD+ Decline in Human Tissue (2012)
Human tissue analysis | Multiple organs studied | Cross-sectional | 10-50% decline with age
Foundational study by Massudi et al. showing NAD+ decreases in skin, brain, heart, and liver by 10-50% during adult aging, correlating with increased oxidative stress and PARP activity.
View study →Nicotinamide Riboside Bioavailability in Humans (2016)
Human | 100-1000mg oral | Single dose pharmacokinetics | Dose-dependent NAD+ elevation
First clinical trial of NR pharmacokinetics demonstrating dose-dependent increases in blood NAD+ metabolome and identifying NAAD as a sensitive biomarker of effective NAD+ repletion.
View study →NMN Efficacy in Middle-Aged Adults (2022)
Human | 300-900mg oral daily | 60 days | Multicenter RCT
Randomized, multicenter, double-blind trial showing NMN supplementation safely and effectively elevated NAD+ metabolism with dose-dependent improvements in physical performance.
View study →